Beta 2 microglobulin b2m is a protein that is found on the surface of nucleated cells contain a nucleus and functions as part of the human immune system. Discover related pathways, diseases and genes to beta 2 microglobulin recombinant protein h00000567p01. It is present in most body fluids and its level rises with conditions that increase cell production andor destruction, or that activate the immune system. Microglobulin definition of microglobulin by medical dictionary. View details of cost of test, pre test information and. Interpretation depends on the specific clinical indication and context. Thenormalstructureandfunction of 2 m are well characterized, and although wild type 2 mis.
Lee biosolutions is the leading producer and supplier of human urine beta 2 microglobulin b2m for use in medical autoimmune research and manufacturing of clinical diagnostic assays. Principle the sdi beta 2 microglobulin elisa test is based on the principle of a solid phase enzymelinked immunosorbent assay. However, with respect to multiple myeloma, the levels of beta2microglobulin may also be at the other end of the spectrum. Mar 28, 2020 beta 2 microglobulin b2m is a naturally occurring protein in the human body. Prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen tests should be performed. It is a powerful prognosis factor for multiple myeloma, a type of bone marrow. It is recommended that each laboratory establish its own normal and pathological ranges of urine levels. A protein found on the surface of many cells, including white blood cells.
It is one of two polypeptide chains that make up the structure of a major histocompatibility complex mhc class i molecule. Beta 2 microglobulin is a molecule that exists on nearly all cells that have a nucleus and to that extent is not a cause of worry. In serum or plasma samples, the reference range is 03 gml. Recombinant human beta 2microglobulin protein h00000567p01. Search in access database datagridview bindingsource filter part 12. Despite its potential role as a convenient and noninvasive prognostic indicator in malignant lymphomas. Beta2 microglobulin kidney disease lab tests online. Complete blood count, metabolic profile with liver function tests, serum ldh level, serum beta2 microglobulin, serum free light chain assay, serum and 24hour urine protein, electrophoresis and immunofixation, a skeletal survey, and bone marrow are all important in the initial workup of mm patients. Guy sherwood the purpose of the bodys immune system is not only to recognize foreign antigens but also to be able to determine between self and not self. Esta proteina existe em quase todas as celulas e correlacionase com a massa tumoral total em divisao presente em neoplasias hematologicas principalmente mm e linfomas. Beta2 microglobulin and creactive protein test results are not specific for waldenstroms macroglobulinemia. Remarkable removal of beta2microglobulin by online. Beta 2 microglobulin is shed by the cells which becomes detectable in the bloodstream under normal conditions.
Diagnostic testing for multiple myeloma includes obtaining the beta2microglobulin level, for this level is an important prognostic indicator. Certain characteristics of b2m make it suitable for detecting tumor cells, especially in blood and kidney cells. Biotechne appreciates the critical role that you and our products and services play in research. Beta2 microglobulin b2m levels increase during infection with some viruses, including hiv. Dr lal pathlabs offers home collection booking service for beta 2 microglobulin serum to test for disorders of kidney. E forte indicador da remissao e recidiva da doenca em pacientes. The aim of this study was to compare urinary alpha 1 microglobulin a1mg in healthy individuals with and without family burden for balkan endemic nephropathy ben in an endemic village. It is known to cause dialysisrelated amyloidosis dra, by virtue of its retention when renal function fails, its deposition in tissues, its aggregation into fibrils, and its ability to become glycosylated. Sep 05, 2014 the reference range of beta 2 microglobulin in urine samples is 00. Serum beta2microglobulin values among healthy brazilians. Elevated concentration levels of beta 2 microglobulin is attributed to diseases with a high cell turnover. Definition beta 2 microglobulin is a protein found on the surface of many cells. Beta 2 microglobulin b2m is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by b lymphocytes and tumour cells. If you choose to print this information, it is valid only on date of print.
Lee biosolutions is the leading producer and supplier of recombinant beta2 microglobulin b2m for use in medical research and manufacturing of clinical diagnostic assays. Sep 25, 2014 beta 2 microglobulin is synthesized in all nucleated cells and forms the light chain subunit of the major histocompatibility complex class i antigen. Beta2 microglobulin an overview sciencedirect topics. Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, nonhodgkins lymphoma, and multiple myeloma or kidney disease. Beta 2 microglobulin is not diagnostic of a given disease but is usually an indicator of disease severity, e. The problem with cancer is that the body does not recognize these malignant cells as being foreign. Beta 2 microglobulin b2m is a protein shed by cells into the blood, including tumor cells. Read the bioinformatics tool guide for instructions on using this tool. The identification of the beta 2 microglobulin binding antigen encoded by the human cd1d gene.
The sdi beta 2 microglobulin elisa kit is intended for the quantitative determination of beta 2 microglobulin b2mg concentration in human serum. Search in access database datagridview bindingsource filter part 12 duration. The implication and significance of beta 2 microglobulin. Microglobulin definition of microglobulin by medical. Pdf the beta 2microglobulinfree heterodimerization of. This protein is routinely shed by cells into the blood and is present in most body fluids, with highest levels in the blood, generally lower levels in spinal fluid, and trace levels in urine. The b2m test can be used as a tumor marker for some people with blood cell cancers multiple myeloma, lymphoma to give information about their likely prognosis. Values of alpha 1 microglobulin does not differ between. The beta 2microglobulin free heterodimerization of rhesus monkey mhc class i a with its normally spliced variant reduces the ubiquitindependent degradation of mhc class i a. Levels of sb 2 m are elevated in human immunodeficiency virus hivinfected patients and have been shown to be the best predictor of hiv infection status and of some malignant disorders, especially multiple myeloma.
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